ABSTRACT
Background: Recent research have found a link between inflammatory pathway and suicidal behaviour. hs-CRP, IL, TNF have been shown to have significant alterations in suicidality, however multiple covariates influence this relationship. One of the main limitations of most of the studies is that they have evaluated the CRP in patients demonstrating suicidal behaviour but not in depression. No study has been conducted in Indian subpopulation with parameters of our study. Aims of the study was to compare hsCRP levels between depression patients with suicidal behaviour and without suicidal behaviour.Methods: Authors compared 50 depression patients with suicidal behaviour and 50 depression patients without suicidal behaviour, diagnosed using ICD10. Hamilton Depression Rating Scale (HDRS‑17), Suicide behaviour Questionnaire- Revised (SBQ-R), Beck Scale for Suicidal Ideation (BSSI) were applied for assessment of depression and suicidality. Highly sensitive CRP was measured using autoanalyzer.Results: hsCRP levels were significantly high in depression patients with suicidal behaviour (4.12 mg/dl) than depression without suicidal behaviour (2.42 mg/dl). Duration of illness, HAM-D, BSSI and SBQ-R scores correlated positively with hsCRP levels.Conclusions: Depression with suicidal behaviour patients have a significantly higher hs-CRP levels than depression without suicidal behaviour. Patients of depression with suicidal behaviour group have a strong positive correlation between hs-CRP levels and HAM-D, BSSI and SBQ-R scores.
ABSTRACT
Introduction: Vitiligo an acquired pigmentary disorderof the skin and mucous membranes characterized by wellcircumscribed, depigmented macules and patches resultingfrom selective destruction of melanocytes. CRP is an acutephase protein secreted by the liver in response to severalinflammatory cytokines such as IL6. Since inflammatoryand immune factors plays a key role in the pathogenesis ofvitiligo, we aimed to assess the relationship between theserum level of hs-CRP and pathogenesis and severity ofvitiligo.Material and methods: The study was conducted in theDept. of Biochemistry and Dept. of Dermatology andVenereology in MGM Medical College & M Y HospitalIndore after approval from ethical committee on 70Confirmed & diagnosed cases of Vitiligo patients of agegroup 18 to 55 years attending Dermatology OPD in MYHospital Indore during a period of April 2018 to April 2019.Patients were divided into three groups according to thearea of skin affected. Healthy individual without vitiligowere taken as controls. Venous blood sample was analyzedfor serum hs-CRP levels and liver function. Appropriatestatistical tests were applied on Minitab Version 17.0 and pvalues < 0.01was considered significant.Results: In our study the mean serum hs-CRP in case groupwas higher 12.09 ± 11.64 than in control group it was 1.99 ±2.05 with negative but statistically significant correlation withage of onset of disease and positive statistically significantcorrelation with duration of disease thus, serum hs-CRPlevel might be useful for evaluating the disease activity ofvitiligo as Novel biomarker.Conclusion: As high-sensitive C-reactive protein (hs-CRP)is an important sensitive diagnostic and prognostic markerin many systemic inflammatory diseases and very lowconcentrations of hs-CRP can be analyzed in the serum, itsdetection and serial measurements helps to provide a novellink to evaluate the disease activity and severity and responseto treatment